variable listing for multiple items with multiple choices

[grammygonewild]

I know how to create a variable listing when you have one item and multiple options, but can I create a variable listing that has many items with multiple options each?  i.e.  If I have 5 different shirts in 4 different colors each with 4 different sizes. Is this possible?

[comics-scifi-collectibles]

@grammygonewild   It would be best to create a listing for each different shirt with the color and size options for that style.  That's how a variation listing works.