To keep the scammers and deadbeats from committing to buy your item (and tying it while you go through the unpaid item process) don't use auctions or Best Offer. List as fixed-price Buy It Now only and set the BIN to Immediate Payment Required. (I'm not familiar with the new listing tool to be able to tell you where (and how (you probably have to click a "show more options" link somewhere)) to find them on that form)
eBay is experimenting with requiring pre-authorization for payment when a buyer makes a Best Offer but that's just an experiment and not applicable to all buyers (as a seller you can opt out--it makes combined shipping discounts difficult to impossible--or into the experiment in your Buyer Requirements). Otherwise auctions and Best Offer (and some Buy It Now) allow the buyer to promise to pay in order to scam you. Note that anyone requesting you to contact them outside the eBay message system (email or text or phone) is almost certainly a scammer trying to get your contact information (e.g. to send you a fake payment message).
Other than that, you set your Buyer Requirements to exclude anyone with 2 or more unpaid item cancellations in the past 12 months and you do the cancellations for nonpayment.
