You can place your store on vacation to display a message to potential buyers that you are away. You can also choose to hide your fixed price listings if you would like. Keep in mind that since this does not affect auction-style listings, these will need to be ended manually before your vacation begins. If you decide not to hide your fixed price listings, be sure that you adjust your stated handling time so your buyer is given an accurate expectation for shipment and delivery. This will also ensure that you do not have any late shipment defects recorded.
To turn on your Store vacation settings:
If you do not have a store and are planning a vacation, you will need to manually end your fixed priced listings and any auctions that are scheduled to end during your time away. Once you return, you can relist your items.
Be aware that potential customers may have questions for you while you are away, so you should set up an out of office reply to let them know when you will return.